Veterinary Ivermectin Tablet锛?/strong> [Pharmacodynamics] Ivermectin has a good repellent effect on nematodes and arthropods in vivo.The mechanism of deinsectization is to promote the release of gamma-aminobutyric acid (GABA) from presynaptic neurons, thus opening gabA-mediated chloride channels.Ivermectin also has selectivity and high affinity for glutamate-mediated chloride channels in invertebrate nerve and muscle cells located near gabA-mediated sites, thus interfering the signal transmission between nerve and muscle, causing relaxation and paralysis of the worm, leading to the death or excretion of the worm.The inhibitory interneurons and excitatory motor neurons of nematodes are the sites of action, while the sites of action of arthropods are the neuromuscular joints.For cattle and sheep, the removal rate of blood pike nematode, Austerworm, Archaea, trichonematode (including Trichonematode), round nematode, openmouth nematode, slender neck nematode, trachea nematode, net tail nematode and sheep summer burt nematode was 97% ~ 100%.It is also effective against arthropods, such as fly maggots, mites and lice.The therapeutic effect on chewing lice and sheep and sheep ticks was slightly worse.Ivermectin is also highly effective against ticks and flies bred in their faeces. Although it does not kill ticks immediately, the drug can affect feeding, molting, and laying of eggs, thereby reducing their reproductive ability.The effect on blood flies is similar.The removal rate of ascaris roundworm, red roundworm, Roundworm, capillaria nematode, tracheostoma nematode, metastrongylostoma nematode, crown tail nematode and immature nematode was up to 94% ~ 100%, and it was also very effective to trichinella intestinalis (trichinella muscularis was not effective), and it also had a good control effect on pig blood lice and sarcotic mite.Not effective against trematodes and tapeworms. The pharmacokinetics of ivermectin vary significantly with the species, dosage form and route of administration.The bioavailability of subcutaneous injection was higher than that of internal administration, but internal administration was more quickly absorbed than subcutaneous injection.After absorption, it distributes well to most tissues, but does not easily enter cerebrospinal fluid.The apparent volumes of distribution of cattle, sheep and pigs were 0.45 ~ 2.4, 4.6 and 4 L/kg, respectively.Most animals have long half-lives, 2-3 days for cattle, 2-7 days for sheep, and 0.5 days for pigs.This product is metabolized in liver, mainly hydroxylation in cattle and sheep, and methylation in pig.Mainly excreted from the stool, less than 5% is excreted from the urine in its original form or as a metabolite.In lactating mothers up to 5% of the dosage is discharged from the milk. [Drug interactions] When used in conjunction with diethylcarbamazine, severe or fatal encephalopathy may occur. Function of the attending Macrolides are antiparasitic drugs.It is used to control nematodes, mites and other parasitic insect diseases in domestic animals. FAQ Q1. Are you GMP manufacture? A: Yes,we are the animal injection veterinary medicine GMP factory with 10 years experiences since 2009. Q2.What kind of veterinary dosage forms of your product? A:We have 3 production lines include Liquid injection,Soluble Powder,Premix, Oral solution,Disinfectant, Powder injection, Pet medicine .China Veterinary Tablet suppliers website:http://www.chunovet.com/veterinary-tablet/